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At the cellular level, AOD-9604 exerts its primary effects through a complex mechanism involving beta-3 adrenergic receptors located on the surface of adipocytes (fat cells)

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Moreover, TMAO can cross the BBB

Assessment of oxidative stress biomarkers in pulmonary tissues Total antioxidant capacity (TAC), reduced glutathione (GSH), malondialdehyde (MDA), and inducible nitric oxide synthase (iNOS) levels were estimated in pulmonary homogenates

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