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In the last decade, in the context of therapeutic strategies against cancer, peptide-based vaccines have been evaluated in different tumor models

Considering the bulky usage of OMZ which is associated with adverse side effects, new drugs should be discovered as aiding/therapeutic agents to inhibit/prevent OMZ-induced psychiatric illness

For researchers dealing with autoimmune conditions or chronic inflammatory states, this modulation rather than suppression mechanism is particularly relevant

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While CD8 + T and CD4 + T H 1 cells suppress angiogenesis and induce vascular maturation by secreting IFN-, they are unable to infiltrate the TME due to malformed tumor vessels