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doi: 10.1038/ncomms6029 [DOI] [PMC free article] [PubMed] [Google Scholar] 81.G ZR

In summary, nearly the entirety of the information on methylene blue causing serotonin syndrome is either theoretically based on pharmacodynamics or is pharmacokinetically based on the use of parenteral methylene blue used in a hospital setting

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Shaking causes foaming and can denature the peptide through mechanical stress

Exercise-induced dynorphin release is linked to increased BDNF expression, which supports neuroplasticity and may contribute to antidepressant effects [100]