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24 , R169R173 (2014)

(1996) reported the analog was 1.5-2x more potent than equimolar IGF-1 in catabolic rat models, and broader pharmacology literature places it at roughly 3x potency overall

The mechanism by which DDP exerted anti-tumor effect is by binding to DNA and initiating cell death ( Inhibition and deletion of xCT depends on whether it induces ferroptosis, inhibits HNC cell apoptosis, and promotes cisplatin-resistant functions

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation
