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These mutations lead to the loss of dopaminergic neurons in the substantia nigra, resulting in motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms such as cognitive impairment and depression

doi: 10.1007/s13318-021-00736-7, 73

however, this is a complex approach that depends on multiple factors

[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Young J, Anwar A

The 5-on/2-off schedule, the bedtime timing, the 3-month cycle with a rest period, the reconstitution method: none of these are suggestions

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