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SSP activation lead to elevated glutathione (GSH) production, cell cycle progression and nucleic acid synthesis, which are essential for cell survival and proliferation especially under nutrient-deprived conditions (66).The relationship between glycolysis and SSP has been described in astrocytes, where glycolytic flux modulates D-serine production through the interaction between serine racemase and a glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) ( Figure 1 ) (67)

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