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PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Borgo C, DAmore C, Sarno S, Salvi M, Ruzzene M

A recent screening-based study has identified several promising SARM1 inhibitors, including non-competitive inhibitors such as berberine chloride and zinc chloride 233 , suggesting the presence of an allosteric binding pocket that can be targeted for therapeutic development

They proposed Semax as an alternative based on several observations from animal and human studies

TB-500 directs stem cells and other repair cells to injury sites, reduces scar tissue formation, and improves tissue flexibility
Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B 12 metabolism
