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The NAD + cofactor binds at the C-terminal end of the parallel beta strands in the N-domain, lying in the cleft between the N and C-domains

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On the other hand, the activation of the compensatory pathway makes it possible for another pathway to enhance compensation when one CYP enzyme is inhibited

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This combined approach of curcumin and OM-MSCs offers a promising and potentially efficacious therapeutic strategy for ischemic stroke, addressing multiple facets of injury, including inflammation and specific forms of cell death (547)