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However, previous studies have not resolved certain questions: i) whether alterations in the identified proteins and metabolites are affected by eye drops, ii) how these changes in proteins and metabolites are affected by glaucoma phenotype, and iii) whether normal-tension glaucoma shows protein and metabolite changes in the same way as POAG

Risk of bias assessment Two reviewers independently appraised the quality of the studies using the Cochrane risk of bias version 2 (RoB-2) tool [30] and disagreements were resolved through consensus

LC can potentially prevent formation of ROS, regulate cell redox status, and activate some molecular pathways which modulate cellular homeostasis, especially in critical conditions