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Pinealectomy stimulates cancer initiation or growth in animals, and pineal calcification, that leads to a decline in melatonin production, have been associated with an increase in pediatric primary brain tumors (72)

To deliver shRNA via adenoviral vectors, 1 10 8 PFU of adenoviral particles (Ad-shBhlhe40 or Ad-shSox9) in 40 l were injected subcutaneously into the exposed dorsal skin 2 d before, on the day of, and 2 d after hair plucking