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Hormonal signals profoundly influence these metabolic fluxes: insulin and insulin-like growth factor 1 (IGF-1) are anabolic hormones that promote glucose uptake and utilization and activate the mTOR pathway, a central regulator of cell growth and protein synthesis [61]

Scientifically rational linker design principles directly determine an ADC's pharmacokinetics, tumor selectivity, and clinical performance

It is rich in growth factors and other cells that signal an increased healing response to a damaged tissue

Allen J, Bradley RD

The low toxicity profile of natural products positions them as a potentially transformative therapeutic strategy for TNBC

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