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Exceeding 25 mg daily without medical supervision may cause copper deficiency, immune impairment, and gastrointestinal disturbances

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Thermogenic Ingredients Some pre-workouts include ingredients like caffeine, green tea extract or L-carnitine that support metabolic activity

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Keller U, van der Wal C, Seliger G, Scheler C, Rpke F, Eder K

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doi: 10.3109/00365521.2010.503969

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When the endoplasmic reticulum (ER) calcium stores are depleted, usually due to receptor-mediated activation of phospholipase C (PLC) and subsequent inositol trisphosphate (IP3) production, the stromal interaction molecule (STIM) undergoes conformational changes and migrates to regions of the ER close to the plasma membrane, where it activates TRP channels [23,24,25]

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