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23 , 24 The synovial space is another site that is greatly affected by ROS in the onset of OA

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As a consequence of these lockstep sequences of reactions, any given enzyme is dependent on the activity of preceding reaction steps for its substrate

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Indeed, GSH covalently binds to some drug molecules in a GST-dependent manner leading to their cellular export and quenches reactive oxidative species often requiring for these compounds to act [27, 28]

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