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Samples were spun for 10 min at 4000 g and supernatants were collected and precleared with magnetic protein-G-dynabeads (Invitrogen)

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In vivo, mitochondrial GPX4 (mGPX4) is essential for the maturation of cone photoreceptors, where the mGPX4 knockout mice exhibit a cone-rod dystrophy-like phenotype due to apoptosis [88]

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