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One of the primary reactions of methylcobalamin in the body is to convert homocysteine to methionine high homocysteine levels are undesirable and known to be an indicator of heart disease and stroke risk due to the fact free homocysteine in the blood causes sclerosis of the arteries, putting strain on the vascular system and the heart

However, no controlled human trial has compared oral versus injectable AOD-9604 at equivalent systemic doses

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When B12 levels fall below optimal ranges, the rapidly dividing cells of the oral mucosa become particularly vulnerable to damage and impaired healing