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Inhibition of the mTOR pathway significantly reduces the inflammatory response in microglia, highlighting how cellular metabolic pathways, particularly the mTOR-HIF-1 pathway, can influence the functional phenotype of microglia (Cheng et al., 2014)

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HSF1 pathway inhibitor clinical candidate (CCT361814/NXP800) developed from a phenotypic screen as a potential treatment for refractory ovarian cancer and other malignancies

Hepatic caspase-3 activity was measured utilizing a colorimetric assay kit purchased from Sigma Aldrich (MO, United States)

10.1016/j.biochi.2019.04.008 Biochimie 49 LuS