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The step-wise dose increases exist to manage GI adaptation
FIGURE 5 Consistent with the protein level changes, quantitative real-time PCR (qPCR) analysis shows that PA significantly downregulates the mRNA expression levels of the crucial anti-ferroptosis genes GPX4, SLC7A11, and NRF2 in both NSCLC cell lines in a dose-dependent manner (Figures 5B,C)
The mechanism of CRF has not been fully elucidated and may be associated with (28,35,36) tumor and host inflammatory response, such as increased IL-1, IL-6 and TNF-
