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Elle agit comme transporteur, acheminant les acides gras de la circulation sanguine vers les mitochondries, les cellules spcialises qui utilisent les graisses pour produire de l'nergie

Landscapes Chemical & Material Sciences (AREA) Organic Chemistry (AREA) General Health & Medical Sciences (AREA) Life Sciences & Earth Sciences (AREA) Biochemistry (AREA) Biophysics (AREA) Health & Medical Sciences (AREA) Genetics & Genomics (AREA) Medicinal Chemistry (AREA) Molecular Biology (AREA) Proteomics, Peptides & Aminoacids (AREA) Analytical Chemistry (AREA) Peptides Or Proteins (AREA) Preparation Of Compounds By Using Micro-Organisms (AREA) Abstract PT141PT141A2Butelase 1PT141 Description 20170726201710619602.9PT141 PT141 PT141(Bremelanotide)alpha-PalatinIIIPT141CICas189691-06-3 Ac-Nle-Cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH I PT141Fmoc-Asp(OAllyl)-OHFmoc-Lys(Alloc)-OHHF CN101857629APT141TFA PT141PT141 PT141 1PT141 2(30175u/mg)(1.510u/mg)A2(1000u/mg)(10000u/mg)(1500u/mg)Butelase 1(5000u/mg)PT141 PT141PT141 pH2-9PBS()pH5-7PBSpH6.0PBS 0-10010-3530 100:11000:1300:1 PT141 1.1PT141LysTrpArgHisAspPT141CNPT141 1.2PT141PT141 PT141(SEQ ID NO:1)NC Nle 1 -Asp 2 -His 3 -D-Phe 4 -Arg 5 -Trp 6 -Lys 7 SEQ ID NO:1Xaa(1)Nle()Xaa(4)D-PheSEQ ID NO:1 1.1 1.1.1LysDMAPLys-PT141CN1 1.1.21NPT141 LysFmoc-Lys(Boc)-OHFmoc-Trp(Boc)-OHFmoc-Arg(Pbf)-OHFmoc-D-Phe-OHFmoc-His(Trt)-OHFmoc-Asp(OtBu)-OHFmoc-Nle-OH SEQ ID NO:1()NNFmocDBLK(20DMF)N(210)1 1.5-42-3(205) wang2-1.0-3.0mmol/g1.0-2.0mmol/g1.3-1.5mmol/gwang2- 2.2mmol/g1.4mmol/gDMFNMPDMF DIC+ADIPEA+A+BAHOBtHOAtBPyBOPPyAOPHATUHBTUTBTUDIC:A1.2:1.1DIPEA:A:B2.0:1.1:1.0 PT141PT141TFAH 2 OPhOMeEDTTFAPhOMeEDTTFAH 2 OPhOMeTFAH2OPhOMeEDT90:5:2:2:1TFAPhOMeEDT95:2.5:2.0:0.5TFAH2OPhOMe90:5:4:1 PT141 0.1/PT14170-80ml/min280nmPT141 0.1/98:250:5080:2060:4070:30 PT14130-9099Butelase 180-9030-40 PT141PT141 1 PT141 1 2FmocFmoc-AA-OHN 3 4PT141 5PT141PT141 11 1 1 11.40mmol Fmoc-Lys(Boc)-Wang 2.2mmol/gWang100gDMF60Fmoc-Lys(Boc)-OH 46.9(100mmol)HOBt16.2(120mmol)DMAP 1.2(10mmol)DMF020.3mLDIC,570mL60mL24DCMFmoc-Lys(Boc)-Wang1401.40mmol/g 2 11.40mmol/gFmoc-Lys(Boc)-Wang50g50mLDMF6050mL DBLK6min+8min100mLDMF6110.5g(210mmol)Fmoc-Trp(Boc)-OH32.8g(210mmol)HOBT150mL DMF36.4mL(210mmol)DIC3min2(1)150mLDMF3150mLDBLK6min+8min150mLDMF6Fmoc-Arg(Pbf)-OHFmoc-D-Phe-OHFmoc-His(Trt)-OHFmoc-Asp(OtBu)-OHFmoc-Nle-OHHOBTDIC210mmol100mL90mL2DMF6100mL200mL82.5Ac-Nle-Asp(OtBu)-His(Trt)-D-Phe-Arg(Pbf)-Trp(Boc)-Lys(Boc)-Wang 3 282.5g1LTFA:H2O:PhOMe:90:5:4:1(V:V)900mL2TFA10L5L557.4,77(57.4/(501.401058)100)87 4 282.5g1LTFA:PhOMe:EDT95:2.5:2.0:0.5(V:V)900mL2TFA10L5L550.568(50.5/(501.401058)100)85 5 282.5g1LTFA:H 2 O:PhOMe:EDT:90:5:2:2:1(V:V)900mL2TFA10L5L560.582(60.5/(501.401058)100))90 6PT141 560.51000ml(pH6.0)700ml0.2g,3010cm25cm0.1/70:3070-80ml/min280nm25.2g99.542(25.21040)(60.51058)100 7PT141 560.51000ml(pH6.0)700ml0.2g,3010cm25cm0.1/ 70:3070-80ml/min280nm19.1g99.532(19.11040)(60.51058)100 8PT141 560.51000ml(pH6.0)700mlA20.2g,3010cm25cm0.1/70:3070-80ml/min280nm26.2g99.544(26.21040)(60.51058)100 9PT141 560.51000ml(pH6.0)700ml0.2g,3010cm25cm0.1/70:3070-80ml/min280nm18.2g99.531(18.21040)(60.51058)100 10PT141 560.51000ml(pH6.0)700mlButelase 10.20g,3010cm25cm0.1/70:3070-80ml/min280nm 52.0g99.588(521040)(60.51058)100 11PT141 560.51000ml(pH6.0)700mlButelase 10.20g,2510cm25cm0.1/70:3070-80ml/min280nm48.0g99.581(481040)(60.51058)100 12PT141 560.51000ml(pH6.0)700mlButelase 10.15g,3010cm25cm0.1/70:3070-80ml/min280nm51.2g99.586(51.21040)(60.51058)100 13PT141(CN101857629A) 560.520DMF 106mmol/l94PyBOP23DIEA10-2024DMF500mL10cm25cm0.1/70:3070-80ml/min 280nm22.3g99.538(22.31040)(60.51058)100 19.7g21.5g33.136.2 Claims (15) PT1411PT1412A2Butelase 1PT141 1pH2-9PBS 10-100 1100:11000:1 111.1PT141LysTrpArgHisAspPT141CNPT1411.2PT141PT141 51.11.1.1LysDMAPLys-PT141CN11.1.21NPT141 6LysFmoc-Lys(Boc)-OHFmoc-Trp(Boc)-OHFmoc-Arg(Pbf)-OHFmoc-D-Phe-OHFmoc-His(Trt)-OH Fmoc-Asp(OtBu)-OHFmoc-Nle-OH 6wang2- 6DIC+ADIPEA+A+BAHOBtHOAtBPyBOPPyAOPHATUHBTUTBTU 6 5TFAH 2 OPhOMeEDTTFAPhOMeEDTTFAH 2 OPhOMe 11TFAH2OPhOMeEDT90:5:2:2:1TFAPhOMeEDT95:2.5:2.0:0.5TFAH2OPhOMe90:5:4:1 1-12PT141 13PT141PT141 14PT1410.1/PT14170-80ml/min280nmPT141 Applications Claiming Priority (2) Publications (1) Family ID=65039962 Family Applications (1) Country Status (2) Cited By (3) Citations (4) Family Cites Families (3) 2017 2017-07-26 CN CN201710619602.9A patent/CN109306366B/zh active Active 2017-11-21 WO PCT/CN2017/111988 patent/WO2019019492A1/zh not_active Ceased

Produkt jest odczynnikiem chemicznym o statusie wycznie badawczym

This is no surprise to us here at Melanoboost HQ as the technology has taken us years to develop and perfect, and the results speak volumes

Fischl Omega-3-Fettsuren sind eine spezielle Gruppe mehrfach ungesttigter Fettsuren, unter denen den biologisch aktiven Omega-3-Fettsuren Eicosapentaensure (EPA

Absolutely not