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Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

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In both PCA, parameters indicating greater viability (higher rate and OD max) were positively correlated with higher levels of GSH (positive component 1) and negatively correlated with higher levels of GSSG (negative component 1) ( Figures 5A,B )

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Small human studies comparing delivery forms have found meaningfully higher blood glutathione levels with liposomal versions compared to standard capsules

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