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[DOI] [PubMed] [Google Scholar] Valdez GR, Sabino V, Koob GF (2004) Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation

Ketone Bodies During periods of fasting and some other physiological conditions, water-soluble molecules that may contain a ketone group, such as acetoacetate, hydroxybutyrate, and the spontaneous breakdown product of acetoacetate, acetone, are produced from acetyl-coA by the liver after oxidation of fatty acids

CoQ10 is a large, highly lipophilic (fat-soluble) molecule

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The shuttle utilizes this to its advantage by attaching the LCFAs to carnitine