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Moreover, NUAK1 inhibition causes tumor ICD through H 2 O 2 /OH accumulation and ER stress, as NRF2, downstream of NUAK1, suppresses antioxidant gene expression [263]

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reported that low dosage of curcumin (160 ppm) administered orally for 6 months reduced both the insoluble amyloid and A plaque burden in APPSw brain respectively by 39% and 43.6%, which were consistent with previous observation in ibuprofen-treated animals [41]

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