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It represents a promising first-line treatment for DPN, preventing early development and progression through both direct and indirect antioxidant effects [8,23,71,87,110] (Figure 3)

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Hematologic Toxicities Hematologic side effects are most pronounced with cytotoxic oral agents such as temozolomide, etoposide, and cyclophosphamide , which target rapidly dividing hematopoietic precursors in the bone marrow