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In contrast, the gut microbiota can inhibit HDAC activity by fermenting inulin into SCFAs, thereby regulating the acetylation level of histones and affecting epigenetic changes in immune cells (75, 76)

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But by staying calm during a cold shower, or a cold bath, you can train your Vegas nerve in a very similar way, actually, as another strategy I talk about in the book: Staying calm during hard exercise

doi: 10.1038/ncb3575

The EMBO Journal e109049 1-29 Roblek, M., Bicher, J., van Gogh, M., Gyoergy, A., Seebock, R