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In addition to its epigenetic and anti-inflammatory properties, curcumin exerts direct antitumor effects in colorectal cancer by modulating key oncogenic signaling pathways, such as nuclear factor kappa B and signal transducer and activator of transcription 3, leading to suppressed proliferation, reduced invasion, and enhanced apoptosis

The dissociation of the cell-cell junctions in ECs is likely mediated by tumor-derived vascular permeability factors, such as SPARC and angiopoietin-like 4 [183,184,185]

They report that quercitin, administered by gavage, effectively reversed the ethanol-induced blockade of TFEB nuclear localization, restoring both lysosome function and autophagic flux to normal

Effects of reduced L-glutathione The action of reduced L-glutathione is based on inhibition of the activity of tyrosinase , an enzyme that is crucial to the melanin production process