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Further studies confirmed its capability to promote macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype

Resveratrol (3,4,5-trihydroxy-trans-stilbene) is a natural polyphenol nonflavonoid compound primarily found in grapes, red wine, berries, and peanuts

Alpha lipoic acid has been studied and proven to be a universal antioxidant
Besides, treatment of kainate group with ALC exerted a protective effect against CA 1 neuronal loss and abnormal mossy fiber sprouting (MFS)

10.1146/annurev-publhealth-031912-114409 5
