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Composed of the light chain subunit solute carrier family 7 member 11 (SLC7A11) and the heavy chain subunit SLC3A2, System Xc imports extracellular cystine, which is then rapidly reduced to cysteine intracellularly (28)

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doi: 10.1530/JOE-14-0676

This tolerance development explains why side effects are most prominent during treatment initiation and dose escalation but decline substantially with continued use