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This work not only highlights GCLC as a potential blood-based biomarker for early PD detection but also unveils its functional role in regulating oxidative stress, mitochondrial stability, and dopaminergic neuroprotection, offering a new perspective for translational intervention

In total, 703 proteins were reliably identified

Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntington's disease

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

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L., Carmichael, M