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Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers

Anpep, also known as aminopeptidase N or CD13, constitutes a multifunctional membrane-bound zinc-dependent metalloprotease that is ubiquitously conserved in renal, intestinal, placental, brain, and hepatic tissues and is also expressed on monocytes and myeloid progenitor cells (Dringen et al., 2001

Although sEH inhibition shows robust barrier protection in mice, questions about dosing, delivery route, and potential vascular off-target effects emphasize the need for early-phase trials with ocular pharmacodynamic endpoints (56, 59)

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