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"New chemical entities", that is, synthetic molecules that the human body has never been previously exposed to in our history
Due to disruption in oxidative phosphorylation, mitochondrial dysfunction was reported following exposure to pesticides

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Oostenbrink C, Villa A, Mark AE, van Gunsteren WF (2004) A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6
T., Parry, G
