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Three of the studies did not detect the products of oxidative metabolism following therapeutic dosing in children [44, 46, 48]

This approach may be particularly effective in tumors with concurrent LKB1 and KEAP1 mutations that exhibit enhanced SHMT-dependent metabolism

Adipose-derived stem cells respond to increased osmolarities

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MYC expression being a common property of all proliferating cells, the intrinsically disordered location of its main functional domains in addition to the protein localization inside the nucleus and its short half-life, collectively these properties raise the challenge to find innovative ways to target MYC without causing unacceptable toxicities