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However, various neurodevelopmental disorder conditions, including ASD, may cause steadily high levels of NO in the brain, promoting abnormal SNO of mitochondrial proteins

Although there is no evidence that supplements are helpful in the treatment of psychosis in general, based on the published studies, we believe that if we can detect MTHFR polymorphism in individuals with various psychiatric diseases, we might be able to differentiate those MTHFR-related psychiatric patients from non MTHFR deficient patients and develop specific clinical treatment strategies, such as folate or methylfolate supplement to reverse the symptoms

Ludwig, M

Studies in rats demonstrated enhanced MG levels in aortic and renal tissues, correlating with elevated systolic blood pressure [64]

Although it has been proposed as an effective biomarker, only EoPE (but not LoPE) is associated with increased PAI-1/PAI-2 ratio [75]

doi: 10.1038/s41586-023-06945-1 82 HlacaNZagarTKastelanMBrajacIPrpic-MassariL