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The poly-dipeptides derived from C9ORF72 hexanucleotide expansions exhibit high affinity for mitochondrial proteins, thereby impairing mitochondrial structural integrity and intracellular transport dynamics, as well as Ca 2+ uptake and ATP synthesis (Fumagalli et al., 2021)

15A & B)

101 Taken together, both caloric restriction and exercise provide the potential therapeutic strategies in therapy against pathologies related to NAD + decline

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In addition, Gln supplementation must be carefully evaluated in patients with elevated glutaminolysis as Gln may be directed towards harmful metabolic pathways that worsen cardiovascular health

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