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La concentracin tolerable resulta ser de 0,3 mg/m 3

The result of the loss of water (and overall volume) leads to the activation of the thirst mechanism ( polydipsia )

Administration Frequency: Due to its long half-life of 20 to 30 hours, it is typically administered once daily or 5 days per week (for EXAMPLE: excluding rest days)

A standard treatment plan starts with 0.25mg per week

In an experimental study carried out by Chen Y et al., 2018, it was determined that, in Sprague Dawley rats fed a High fat diet (HFD) during 12 weeks, the authors demonstrated that APS1 significantly reduced body weight and also reduced the accumulation of hepatic lipids regulating the expression of SIRT-1/PGC-1/SREBP-1, as well as the increase in hepatic antioxidant activity on modulating the expression of activity of NRF-2 and HO-1 [51]

Excitotoxic cell death