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Most protocols recommend monthly increases until reaching 10-15mg or until side effects necessitate holding at current dose

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These putative metabolites can be subjects of further evaluation to confirm identity and any pharmacological activity
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CXB1-Pde6brd10/J), WT mice (C57BL/6J) and Rho P23H mice (B6.129S6(Cg)- Rho tm1.1Kpal /J) were obtained from the Jackson Labs
