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It inhibits the NF-kB p65 pathway by blocking phosphorylation at Ser536 and preventing nuclear translocation

186 TomitaN.MorishitaR.TaniyamaY.KoikeH.AokiM.ShimizuH.et al (2003)

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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels