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Some studies involved trisomy 16 mouse models in order to get a basis before clinical trials on DS humans because these mice have increased oxidative stress and cerebral pathology similar to DS [51, 52, 53, 54]

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(4) Complex Ferroptosis involves multiple signaling pathways and molecular regulatory networks, including iron metabolism, lipid metabolism, antioxidant system, etc., which reflects the complexity of the ferroptosis pathway and provides a potential target for clinical intervention in related diseases ( Table 1 Overview of cell death types

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Ziller MJ, Mller F, Liao J, Zhang Y, Gu H, Bock C, Boyle P, Epstein CB, Bernstein BE, Lengauer T
