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The current format has several clinical conditions visited multiple times (particularly obesity) and it might be worth considering how GSHR interactions with multiple other receptors may come into play in therapeutics. Response: We have reorganized the paper to discuss first the molecular mechanisms of all the dimers, followed by a separate discussion of possible ways to leverage these dimers to aid in therapeutics

Why Retatrutide Combinations Remain Unexplored Unlike cagrilintide, which Novo Nordisk has actively studied in combination with their GLP-1 agonist semaglutide, retatrutide has been developed primarily as a monotherapy by Eli Lilly [11]