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269 In this regard, high SIRT6 levels have been reported in colon cancer samples, which correlate with worse prognosis
Mitochondrial function has been shown to decline with age, at least in part due to oxidative damage and mtDNA mutations [155]
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In contrast, prolonged exposure to high levels of NO inhibits ryanodine activity and prevents calcium release (152, 162)
US 09592272 (2017)
Irrespective of its mechanism of action, cuprizone is a widely utilised and validated toxin for modelling CNS demyelination that is not directly associated with peripheral autoimmunity 20
