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In the same study, elevated oleic acid levels enhanced -Syn toxicity, whereas inhibiting stearoyl-CoA desaturase, the enzyme responsible for oleic acid production, provided a protective effect (Fanning et al., 2019)

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Previous studies have demonstrated that fluoromethylcholine (FMC), a non-lethal, microbe-friendly inhibitor of CutC lyase, significantly reduces plasma TMAO levels by irreversibly modifying the enzymatic pair CutC/D within gut microbiota harboring the corresponding gene cluster (Benson et al., 2023)