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As an example, Liu and co-workers designed a Fe 2+ -contained and PEG-modified nanocatalyst reacting with overexpressed H 2 O 2 to generate sufficient OH, which is able to kill tumor cells (Huo et al., 2019)

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This excessive production of radical oxidants can occur in pathological states where mitochondrial function is impaired [3], as is common in numerous metabolic diseases [46], as well as infection