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Nrf2, a key player in this process, is responsible for the activation of the antioxidant response element and subsequent expression of antioxidant enzymes

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A total of 80 metabolites which belong to different categories were identified

Depending on the type of broken DNA, the various pathways, Base-Excision Repair (BER), Nucleotide Excision Repair (NER), Mismatch Repair (MMR), Homologous Recombination (HR), Non-Homologous End-Joining (NHEJ), Interstrand Crosslink (ICL) repair, and other direct repair pathways, can be activated separately or in combination to repair DNA damage

Furthermore, it is a relatively recent hypothesis that 7nAChRs may indirectly influence neuronal behavior by regulating oxidative stress, inflammation, and apoptosis, which is becoming increasingly prevalent
