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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity), completed in 2023 with over 17,600 participants, demonstrated a 20% reduction in major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity but without diabetes

The results revealed that 347 genes were down-regulated and 573 genes were up-regulated following 1D228 treatment (Red dots indicate up-regulated genes in the group, blue dots indicate down-regulated genes in the group, and gray dots indicate non-significant differentially expressed genes)

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And so I do try to stop eating by 7:00 PM

J., Kamphorst, J