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Treatment recommendations are based on provider evaluation, medical history, current medications, and clinical judgment

The participants were randomly assigned to receive metformin 850 mg twice daily or placebo for 3.2 years, and those in the metformin group received metformin for an additional 9 years

Positive immunostaining for SMA antibody has been shown in all OMA lesions [25, 26]

However, despite the encouraging evidence, gaps in our knowledge remain to be filled in order to fully understand the mechanisms connecting NNMT with MetS-related disorders and to develop clinical agents against NNMT

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