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NF-B pathway is the most important way to regulate the transcription of pro-inflammatory cytokines such as IL-6, IL-1 and TNF-, and also plays a vital role in the expressions of inducible nitric oxide synthase (iNOS) and COX-2 (164)

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The primary functions of COX-1 are to maintain the integrity of the gastric mucosa and to control gastric blood flow and acid secretion, whereas COX-2 enzyme activated during an inflammatory response upregulates prostaglandin synthesis at the location of ulceration (Mizuno et al

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J Pharm Sci 107:14541460 Meng X, Wei M, Wang D, Qu X, Zhang K, Zhang N, Li X (2020) The protective effect of hesperidin against renal ischemia-reperfusion injury involves the TLR-4/NF-B/iNOS pathway in rats