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Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways

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Glutathione is involved in detoxification by binding to fat- soluble toxins, such as heavy metals, solvents, and pesticides, and transforming them into a water-soluble form that can be excreted in urine

Protects against free radical damage by cigarette smoke, UV rays, air pollution and harsh chemicals

Alongside physical symptoms, the very common chronic inflammatory disease rosacea contributes to increased levels of oxidative stress as well as other pathogenetic factors

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