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To enhance its functionality, the fragment has been modified with a tyrosine substitution and a stabilizing disulfide bridge
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Reactive oxygen species (ROS) may play an important role in activation of DCs [52] and increase the DC ability to activate CD4 + T cells [53]
Nevertheless, Apretude injections maintained about the same rate of superior overall protection against HIV compared with oral PrEP as seen during the trials blinded period
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