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As key sensors of hemodynamic forces, ECs are constantly exposed to blood flow-induced shear stress, which exert divergent effects on metabolism depending on the flow pattern

Thus, this review provides valuable insights for developing structure-based therapeutics against key proteins involved in AD and PD.

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The treated mice resisted diet-induced obesity, showing lower fat accumulation and better glucose control, which implies MOTS-c can counteract the negative effects of a high-fat diet on weight gain and insulin action

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