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The evolution of this phenomenon results in the pathological increase of the normal excavation of the optic papilla, which eventually results in a serious vision deficit

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Microglia produces QA, then following saturation of KMO enzyme in microglia production of kynurenic acid (KYNA) in astrocytes is promoted [126]

A small clinical trial (N = 82 LOE 1b) in 2013 showed that LC supplementation improved disease indicators and nutritional status in ALS patients with daily supplementation of 1000 mg LC in 40 patients aged 40 to 75 years, while the control group was still given the same amount of placebo [21]