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It is induced by mutations in the gene encoding 3-hydroxysterol- 7 -reductase (DHCR7), the enzyme catalyzing cholesterol formation by 7-dehydrocholesterol reduction

Cholesterol is obtained by extraction from surface membranes of cells of peripheral tissues by two basic mechanisms, although the relative contributions of each are uncertain

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CDT-induced F-actin depolymerization triggers septin redistribution to the membrane, where they organize into ring-like structures, guiding microtubule growth through interactions with proteins like the end binding 1 (EB1) and the end binding 3 (EB3) [205,223]

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