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We observed a tendency for a synergistic effect, as indicated by interaction indices lower than 1 of 0.52 and 0.64 for the 1:1 and 3:1 dose ratio, respectively

Accumulating evidence suggests that stress can activate an inflammatory response in the brain that may contribute to the risk of mental illness, depression, and other stress-related diseases (6, 7)

But, there are several reports supporting an association between inadequate B12 levels and premature hair graying, which is grey hair that onsets before the ages of 20-30 (depending on the demographic) (12)

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Supplements Vitamin B 12 is available over-the-counter as a single-nutrient supplement and also as a component of multivitamin and vitamin B-complex supplements (129)

For many others, high-dose oral B12 works just as well (NIH ODS